Dayang Chem (Hangzhou) Co., Ltd. is one of the leading manufacturers and suppliers of rabeprazole sodium cas 117976-90-6 in China, specialized in providing high quality customized chemicals. Welcome to wholesale bulk rabeprazole sodium cas 117976-90-6 made in China here and get pricelist from our factory. Good service and reasonable price are available.
Product Introduction:
1. Specification
|
Appearance |
White to off-white powder |
|
Assay |
98.0% Min |
|
Melting Range |
140~141 |
|
Loss on Drying |
1.0% Max |
The latest specifications and COA will be sent upon request.
2. Packaging & shipping
|
Packaging |
Bulk Packaging: 10kg ,25kg bag or drum or custom packaging upon request |
|
Transport Classification |
Not regulated as a dangerous good |
|
Lead Time |
in stock |
|
Shipping Methods |
DHL, FedEx, air freight or sea freight |
3. Applications
Rabeprazole sodium(LY307640 sodium) is an antiulcer drug in the class of proton pump inhibitors.Target: Proton PumpRabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to an active sulfenamide. When studied in vitro, rabeprazole is chemically activated at pH 1.2 with a half-life of 78 seconds.
4. Spectrum
5. Related Articles
1. Development of alginate-reinforced chitosan nanoparticles utilizing W/O nanoemulsification/internal crosslinking technique for transdermal delivery of rabeprazole.Life Sci. 110(1) , 35-43, (2014)
2. Eradication of Helicobacter pylori according to 23S ribosomal RNA point mutations associated with clarithromycin resistance.J. Infect. Dis. 208(7) , 1123-30, (2013)
3. Increased gap density predicts weakness of the epithelial barrier in vivo by confocal laser endomicroscopy in indomethacin-induced enteropathy. Shi S, Wang H, Gao H, et al.Dig. Dis. Sci. 59(7) , 1398-405, (2014)
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