Dayang Chem (Hangzhou) Co., Ltd. is one of the leading manufacturers and suppliers of ondansetron hydrochloride cas 99614-01-4 in China, specialized in providing high quality customized chemicals. Welcome to wholesale bulk ondansetron hydrochloride cas 99614-01-4 made in China here and get pricelist from our factory. Good service and reasonable price are available.
Product Introduction:
1. Specification
|
Appearance |
White to off-white powder |
|
Assay |
98.0% Min |
|
Melting Range |
178.5~179.5 |
|
Loss on Drying |
1.0% Max |
The latest specifications and COA will be sent upon request.
2. Packaging & shipping
|
Packaging |
Bulk Packaging: 10kg ,25kg bag or drum or custom packaging upon request |
|
Transport Classification |
Not regulated as a dangerous good |
|
Lead Time |
in stock |
|
Shipping Methods |
DHL, FedEx, air freight or sea freight |
3. Applications
Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.Target: 5- HT ReceptorIC50 Value: in vitro: 5-HT evoked transient inward currents (EC50 = 3.4 microM; Hill coefficient = 1.8) that were blocked by the 5-HT3 receptor antagonist ondansetron (IC50 = 103 pM) . The 5-HT3A receptor antagonist ondansetron (0.3 nM) reversibly inhibited the 5-HT (30 microM) signal by 70% and at 3 nM it abolished the response .in vivo: Acute ondansetron administration at the lowest dose (0.1 mg/kg, IP) tested had no effect, while other doses (0.33 and 1 mg/kg, IP) produced improvements in auditory gating . Different doses of ondansetron were injected intraperitoneally (i.p.) at fixed times during the day to determine both the sublethal (TD50) and lethal (LD50) doses, which were, respectively, 3.7 +/- 0.6 mg/kg and 4.6 +/- 0.5 mg/kg . ondansetron (0.25-1.0 mg/kg, subcutaneously) given before the challenge dose of ethanol (2.4 g/kg, intraperitoneally) injection, significantly and dose dependently attenuated the expression of sensitization. In addition, ondansetron (1.0 mg/kg, subcutaneously) given before ethanol injection on days 1, 4, 7, and 10 significantly blocked the development (days 1, 4, 7, and 10), and expression (day 15) of sensitization to the locomotor stimulant effect of ethanol injection . Toxicity: Ondansetron may be safe in lower doses used to prevent nausea and vomiting in radiation treatment or postoperatively. However, as there is a report that a lower dose of ondansetron prolonged the QT interval in healthy volunteers, this needs to be clarified by the FDA .
4. Spectrum
5. Related Articles
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