Dayang Chem (Hangzhou) Co., Ltd. is one of the leading manufacturers and suppliers of agomelatine cas 138112-76-2 in China, specialized in providing high quality customized chemicals. Welcome to wholesale bulk agomelatine cas 138112-76-2 made in China here and get pricelist from our factory. Good service and reasonable price are available.
Product Introduction:
1. Specification
|
Appearance |
White to off-white powder |
|
Assay |
98.0% Min |
|
Melting Range |
107~109 |
|
Loss on Drying |
1.0% Max |
The latest specifications and COA will be sent upon request.
2. Packaging & shipping
|
Packaging |
Bulk Packaging: 10kg ,25kg bag or drum or custom packaging upon request |
|
Transport Classification |
Not regulated as a dangerous good |
|
Lead Time |
in stock |
|
Shipping Methods |
DHL, FedEx, air freight or sea freight |
3. Applications
Agomelatine is a competitive antagonist of human and porcine serotonin (5-HT2C) receptors (pKi = 6.2 and 6.4, respectively) as well as human 5-HT2B receptors (pKi = 6.6). IC50 value: 6.2 (pKi, 5-HT2c); 6.6 (pKi, 5-HT2b)Target: 5-HT2C Receptor; 5-HT2B receptorIt is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Activation of 5-HT2C receptors by serotonin inhibits dopamine and norepinephrine release. Antagonism of 5-HT2C results in an enhancement of DA and NE release and activity of frontocortical dopaminergic and adrenergic pathways. Agomelatine is also a potent agonist at melatonin receptors which makes it the first melatonergic antidepressant. Agomelatine is an antidepressant drug.
4. Spectrum
5. Related Articles
1. [The activity of glutathione antioxidant system at melaksen and valdoxan action under experimental hyperthyroidism in rats].Biomed. Khim. 59(5) , 541-9, (2013)
2. [Tachycardia and precordial pain with agomelatine: a case report].Therapie. 68(5) , 324-5, (2013)
3. Agomelatine, melatonin and depressive disorder.Expert Opin. Investig. Drugs 22(4) , 407-10, (2013)
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