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Product Introduction:
1. Specification
|
Appearance |
White to off-white powder |
|
Assay |
99.0% Min |
|
Loss on Drying |
1.0% Max |
The latest specifications and COA will be sent upon request.
2. Packaging & shipping
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Packaging |
R&D Sample Sizes: 1 g, 10 g, 100 g and 1kg bottle or aluminum bag for laboratory evaluation. |
|
Transport Classification |
Not regulated as a dangerous good |
|
Lead Time |
in stock |
|
Shipping Methods |
DHL, FedEx, air freight or sea freight |
3. Applications
Schisandrin B(Wuweizisu-B) is a dibenzocyclooctadiene derivative isolated from Fructus Schisandrae, has been shown to produce antioxidant effect on rodent liver and heart.IC50 value:Target: in vitro: Schisandrin B exhibits anti-inflammatory activity through modulation of the redox-sensitive transcription factors Nrf2 and NF-B. SB inhibited mitogen-induced proliferation and cytokine secretion by lymphocytes . Sch B can protect neuronal cells against oxidative challenge, presumably by functioning as a hormetic agent to sustain cellular redox homeostasis and mitoenergetic capacity in neuronal cells . Sch B exerted significant neuroprotective effects against microglial-mediated inflammatory injury in microglia-neuron co-cultures. Sch B significantly downregulated pro-inflammatory cytokines, including nitrite oxide (NO), tumor necrosis factor (TNF)-, prostaglandin E(2) (PGE(2)), interleukin (IL)-1 and IL-6 . Sch B could inhibit TGF- induced EMT of 4T1 cells and of primary human breast cancer cells .in vivo: Similar anti-inflammatory effects of SB on lymphocyte proliferation and cytokine secretion were also observed in vivo . Treatment with Sch B in CsA-treated mice significantly suppressed the elevation of blood urea nitrogen (BUN) and serum creatinine levels and attenuated the histopathological changes. Additionally, Sch B also decreased renal MDA levels and increased GSH levels in CsA-treated mice .
4. Spectrum
5. Related Articles
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