Dayang Chem (Hangzhou) Co., Ltd. is one of the leading manufacturers and suppliers of 5-methyl-1h-pyrazole-3-carboxylic acid cas 402-61-9 in China, specialized in providing high quality customized chemicals. Welcome to wholesale bulk 5-methyl-1h-pyrazole-3-carboxylic acid cas 402-61-9 made in China here and get pricelist from our factory. Good service and reasonable price are available.
Product Introduction:
1. Specification
|
Appearance |
Colorless to pale yellow crystalline solid |
|
Assay |
98.0% Min |
|
Melting Range |
240~241 |
|
Loss on Drying |
1.0% Max |
The latest specifications and COA will be sent upon request.
2. Packaging & shipping
|
Packaging |
Bulk Packaging: 10kg ,25kg bag or drum or custom packaging upon request |
|
Transport Classification |
Not regulated as a dangerous good |
|
Lead Time |
in stock |
|
Shipping Methods |
DHL, FedEx, air freight or sea freight |
3. Applications
AS057278 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant non-peptidic D-amino acid oxidase (DAAO) inhibitor with an IC50 value of 0.91 M and EC50 of 2.2-3.95 M. AS057278 can normalize phencyclidine (PCP)-induced prepulse inhibition in mice. AS057278 can be used for researching schizophrenia.
4. Spectrum
5. Related Articles
1. Changes in the plasma concentrations of D-kynurenine and kynurenic acid in rats after intraperitoneal administration of tryptophan enantiomers.Chirality 22 , 901-916, (2010)
2. A series of D-amino acid oxidase inhibitors specifically prevents and reverses formalin-induced tonic pain in rats.J. Pharmacol. Exp. Ther. 336 , 282-293, (2011)
3. In vitro and in vivo pharmacological profile of AS057278, a selective d-amino acid oxidase inhibitor with potential anti-psychotic properties.Eur. Neuropsychopharmacol. 18(3) , 200-14, (2008)
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