Aldosterone CAS 52-39-1

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Applications

Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level.

Spectrum

Related Articles

1. Cistrome of the aldosterone-activated mineralocorticoid receptor in human renal cells.

FASEB J. 29 , 3977-89, (2015)

2. Finerenone Impedes Aldosterone-dependent Nuclear Import of the Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1.

J. Biol. Chem. 290 , 21876-89, (2015)

3. Sodium homeostasis is preserved in a global 11-hydroxysteroid dehydrogenase type 1 knockout mouse model.

Exp. Physiol. 100 , 1362-78, (2015)

4. Oxidative DNA damage in kidneys and heart of hypertensive mice is prevented by blocking angiotensin II and aldosterone receptors.

PLoS ONE 9(12) , e115715, (2015)

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