Dayang Chem (Hangzhou) Co., Ltd. is one of the leading manufacturers and suppliers of amentoflavone cas 1617-53-4 in China, specialized in providing high quality customized chemicals. Welcome to wholesale bulk amentoflavone cas 1617-53-4 made in China here and get pricelist from our factory. Good service and reasonable price are available.
Product Introduction:
1. Specification
|
Appearance |
Pale yellow crystals |
|
Assay |
98.2% Min |
|
Melting Range |
299~300 |
|
Loss on Drying |
1.0% Max |
The latest specifications and COA will be sent upon request.
2. Packaging & shipping
|
Packaging |
Bulk Packaging: 10kg ,25kg bag or drum or custom packaging upon request |
|
Transport Classification |
Not regulated as a dangerous good |
|
Lead Time |
in stock |
|
Shipping Methods |
DHL, FedEx, air freight or sea freight |
3. Applications
Amentoflavone is a natural biflavone compound with many biological properties, including anti-inflammatory, antioxidative, and neuroprotective effects.IC50 value:Target:In vitro: In irradiated v79 cells, Pretreatment with amentoflavone 24 hours prior to 8 Gy 60Co -ray irradiation significantly inhibited apoptosis, promoted the G2 phase, decreased the concentration of ROS and mitochondrial mass . Amentoflavone dose-dependently inhibited the viability of SW480 cells, and a high concentration of amentoflavone (150 mol/L) obviously induced apoptosis of the cells . In vivo: In epilepsy models, amentoflavone effectively prevented pilocarpine-induced epilepsy in a mouse kindling model, suppressed nuclear factor-B activation and expression, inhibited excessive discharge of hippocampal neurons resulting in a reduction in epileptic seizures, shortened attack time, and diminished loss and apoptosis of hippocampal neurons .
4. Spectrum
5. Related Articles
1. Amentoflavone protects hippocampal neurons: anti-inflammatory, antioxidative, and antiapoptotic effects.Neural Regen. Res. 10 , 1125-33, (2015)
2. Simultaneous extraction of flavonoids from Chamaecyparis obtusa using deep eutectic solvents as additives of conventional extractions solvents.J. Chromatogr. Sci. 53 , 836-40, (2015)
3. Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships.J. Nat. Prod. 70 , 1278-82, (2007)
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