Dayang Chem (Hangzhou) Co., Ltd. is one of the leading manufacturers and suppliers of moclobemide cas 71320-77-9 in China, specialized in providing high quality customized chemicals. Welcome to wholesale bulk moclobemide cas 71320-77-9 made in China here and get pricelist from our factory. Good service and reasonable price are available.
Product Introduction:
1. Specification
|
Appearance |
Colorless to pale yellow solid |
|
Assay |
99.5% Min |
|
Melting Range |
136~137 |
|
Loss on Drying |
1.0% Max |
The latest specifications and COA will be sent upon request.
2. Packaging & shipping
|
Packaging |
Bulk Packaging: 10kg ,25kg bag or drum or custom packaging upon request |
|
Transport Classification |
Not regulated as a dangerous good |
|
Lead Time |
in stock |
|
Shipping Methods |
DHL, FedEx, air freight or sea freight |
3. Applications
Moclobemide(Ro111163) is a reversible monoamine oxidase inhibitor (MAOI) selective for isoform A (RIMA) used to treat major depressive disorder.Target: Monoamine OxidaseMoclobemide orally administered 2 hours before decapitation preferentially inhibits MAO-A and PEA in rat brain with ED50 of 7.6 mol/kg and 78 mol/kg, respectively. Moclobemide orally administered 2 hours before decapitation preferentially inhibits MAO-A and PEA in rat liver with ED50 of 8.4 mol/kg and 6.6 mol/kg, respectively. Moclobemide (0.1 mM), which inhibits brain MAO-A activity by over 80%, does not affect benzylamine oxidase (rat heart) and diamine oxidase (rat small intestine) activity in vitro . Moclobemide (10 mM-100 mM) includes in the culture medium during anoxia or with glutamate significantly increases in a concentration-dependent manner the amount of surviving neurons compared to controls in neuronal-astroglial cultures from rat cerebral cortex .Moclobemide (10 mg/kg p.o.) induces a significant decrease of all monoamine metabolites measured in rat brain . Moclobemide, given via the drinking water (4.5 mg/kg/day), produces significant decreases in adrenal weight of rats after 5 (-23%) and 7 weeks (-16%) of treatment. Moclobemide upregulates hippocampal mineralocorticoid receptor (MR) levels in rats by 65%, 76% and 19% at 2 weeks, 5 weeks and 7 weeks of treatment, and upregulates Glucocorticoid receptor (GR) levels in this limbic brain structure by 10% at 5 weeks. Moclobemide treatment (5 weeks, 4.5 mg/kg/day) significantly attenuates stress (30 min novel environment)-induced plasma ACTH (-35%) and corticosterone (-29%) levels .
4. Spectrum
5. Related Articles
1. Antidepressant-like effect of the novel MAO inhibitor 2-(3,4-dimethoxy-phenyl)-4,5-dihydro-1H-imidazole (2-DMPI) in mice.Prog. Neuropsychopharmacol. Biol. Psychiatry 39(1) , 31-9, (2012)
2. [Serotonin syndrome in the course of drug-poisoning--case presentation].Prz. Lek. 68(8) , 523-6, (2011)
3. [Obstructive sleep apnoea syndrome as the cause of atypical depression].Fortschr. Neurol. Psychiatr. 79(9) , 531-4, (2011)
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